Databases and Knowledge Bases

    PharmaInformatic develops ADME/Tox knowledge bases to optimise and accelerate drug discovery and development:

    Plasma Protein Binding Knowledge Base (PPB-DB):

    • contains more than 21.000 data records on protein binding
    • experimental results obtained from more than 2.800 scientific publications
    • data records are comprehensively curated and annotated
    • knowledge base to evaluate protein binding of compounds



    Preclinical And Clinical Trials Knowledge Base on Bioavailability (PACT-F):

    • contains experimental bioavailability results of clinical trials and preclinical trials
    • largest knowledge base on bioavailability worldwide (>28.000 data records)
    • experimental results obtained from more than 8.100 scientific publications
    • extensively annotated: more than 21 fields describe in detail the results and conditions
    • knowledge base to evaluate uptake of drugs in humans ==> IMPACT-F



    The knowledge base PACT-F has been used

    PACT-F is the fundamental knowledge base to analyse the factors and conditions which influence bioavailability. It provides scientists with the results and knowledge of 100 years of bioavailability research in order to improve future drug design and drug development.

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PharmaInformatic provides
 Knowledge Bases

 and Expert Systems
to improve drug discovery
and development.