The database development started in 2005, it now contains:
Plasma Protein Binding Database
Drugs and toxic substances can be bound to proteins in plasma or blood, which reduces the free (effective) concentration of compounds in vivo. For toxicity evaluations and in drug discovery it is important to know to which extend a compound is bound to plasma proteins:
Data records are comprehensively curated and annotated with up to 20 data fields describing the species, exp. conditions & methods (EQ, UF, UC, GF, albumin binding), compound concentration, etc.
The technology will be available for licensing as a software tool in Q3/2018.
If you have experimental plasma protein data on previous compounds, we can forecast these compounds, so you obtain an independent evaluation of the quality, prior to licensing. Contact us for further details (email).
Plasma protein binding data from different species: